Yes, of course, it has an effect on precision and print surface quality. All extraneous movement of the extruder nozzle relative to the print/bed results in visible artifacts. Extraneous movement comes from flexible frames and end-supported guide rails, bent Z axis threaded rods, and wobbly bearings. Precision starts with fixing these types of problems, including making a rigid frame.
If you want to see one way of doing it right, click the link in my sig, below.
Ultra MegaMax Dominator 3D printer: [
drmrehorst.blogspot.com]