Nyloc nuts everywhere?

I am in the process of designing a printer, and intend to use plastic-insert lock nuts everywhere. The only exceptions will be screws that are designed for regular adjustment (-ie bed leveling, belt/cable tension, and extruder spring pressure.) Are there any other exceptions, or general reasons NOT to use nyloc nuts for general fastening on the frame/bearings/etc? I have done some research on the topic, but haven't found any kind of "best practice" wisdom.

Nylock nuts are fine, even inside a warm printer enclosure, but a little bit of a PITA because you have to use a wrench with them. Other options are to use star-type lock washers and thread locker like Locktite.

Split ring lock washers don't lock.

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Ultra MegaMax Dominator 3D printer: [drmrehorst.blogspot.com]

Nyloc nuts are a pain in hex nut pockets

Usually just round out or break printed nut pocket

Get wrenches to hold nyloc nuts (small metric open end or boxed end wrenches)
Some may have to be pre threaded --- run bolt in - out --- to be used

A dab of thread lock post fastening works well

Thanks for your responses.

Good to know that nylocs destroy printed nut traps, as that's the typical use case in my design. @the_digital_dentist I had assumed star washers would simply chew up the printed surface- do you have any personal experience with this setup?

Maybe I'll just stick to regular nuts, and apply some thread locker if I notice any loosening.

Be careful with thread lockers, the vapors from their curing can weaken plastics. In model helicopters the general advice is to never use thread locker for any bolt used to join plastic parts.