I'm having a few issues printing PLA.
I discovered that many of my printing problems were caused by extruding too much filament, because my E steps per mm was set too high. I used Slic3rs extrusion multiplier setting to crank this down. Win!
However, now I don't always get a consistent extrusion - for instance sometimes my bottom layer will come out "patchy" in places, because the filament comes out in blobs rather than a line. It happens most frequently on the bottom layer, but it's happened on a higher layer too particularly when building up a wall.
I run at 182C hot-end and 65C bed. It's possible that a higher hot-end temperature would help, but I've generally found that this makes a blobby mess.
I think I've got my bed height correct - I recently got a glass plate and levelled it. The hot-end squishes the base layer slightly.
My nozzle is 0.35mm. My layer height is 0.25 mm and I manually set width/height to 1.4 (so that width would be 0.35mm, presumably).
Is there anything else I can try tweaking? Would lowering my width/height help?