Perimeters IS the number of "layers" perpendicular to the face. If you have 2 perimeters, the printer will go around the perimeter twice, one bead inside the other. I don't know about slic3r, but skeinforge has a skin plugin; I assume slic3r has something similar. This allows you to have multiple vertical perimeters (i.e. one on top of the other) within the same space as a normal layer. This makes it look from the outside that you sliced/printed at twice the resolution, but you don't have to wait twice as long for the print to complete.