From my early testing, this STOP button isn't functioning on the PanelDue while it is homing or doing the G29 or G30 routines. In my case, as it was homing the Z axis, the DC42 IR sensor was not triggering properly and it was ramming the nozzle into my PEI bed. Not sure how or why, but the DC42 IR sensor was reading 12 when nothing was close and then 174 when it was trying to run into the bed. After hitting the STOP button a few times, it was halted by the Emergency Stop button on the DWC.
As far as the DC42 IR sensor, I pulled out the 3 pin connector waited a few seconds and then plugged it back in and everything was back to normal. Not quite sure how it had gotten stuck into the weird reading state unless it was 1 in a million chance of the sun reflecting off the PEI sheet when I powered the printer up.