I have the same problem, I have got it to work by creating a .bat file that runs slic3r. I also moved Slic3r to someplace where there is also english chars. like C:\Slic3r Put the bat file in the dir of your slic3r and run it. It will create a dir named Slic3rData in C:\ for it to have the temp files and settings. I have noticed that it often crashes if I load another file and try to slice it.by Clark_Kent - Slic3r